Enhancing production of ergosterol in Pichia pastoris GS115 by over-expression of 3-hydroxy-3-methylglutaryl CoA reductase from Glycyrrhiza uralensis

• Main Authors: Ying Liu (Author), Xiaoqing Zhu (Author), Wendong Li (Author), Hao Wen (Author), Ya Gao (Author), Yong Liu (Author), Chunsheng Liu (Author)
• Format: Book
• Published: Elsevier, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The rate-limiting enzyme in the mevalonic acid (MVA) pathway which can lead to triterpenoid saponin glycyrrhizic acid (GA) is 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). In order to reveal the effect of copy number variation in the HMGR gene on the MVA pathway, the HMGR gene from Glycyrrhiza ur...