Enhancing production of ergosterol in Pichia pastoris GS115 by over-expression of 3-hydroxy-3-methylglutaryl CoA reductase from Glycyrrhiza uralensis

• Egile Nagusiak: Ying Liu (Egilea), Xiaoqing Zhu (Egilea), Wendong Li (Egilea), Hao Wen (Egilea), Ya Gao (Egilea), Yong Liu (Egilea), Chunsheng Liu (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2014-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The rate-limiting enzyme in the mevalonic acid (MVA) pathway which can lead to triterpenoid saponin glycyrrhizic acid (GA) is 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). In order to reveal the effect of copy number variation in the HMGR gene on the MVA pathway, the HMGR gene from Glycyrrhiza ur...