The role of nuclear organization in trans-splicing based expression of heat shock protein 90 in Giardia lamblia.

• Main Authors: Vinithra Iyer (Author), Sheetal Tushir (Author), Shreekant Verma (Author), Sudeshna Majumdar (Author), Srimonta Gayen (Author), Rakesh Mishra (Author), Utpal Tatu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hsp90 gene of G. lamblia has a split nature comprising two ORFs separated by 777 kb on chromosome 5. The ORFs of the split gene on chromosome 5 undergo transcription to generate independent pre-mRNAs that join by a unique trans-splicing reaction that remains partially understood. The canonical cis-a...