Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor

• Main Authors: Romain Duroux (Author), Nicolas Renault (Author), Joana Esteves Cuelho (Author), Laurence Agouridas (Author), David Blum (Author), Luisa V. Lopes (Author), Patricia Melnyk (Author), Saïd Yous (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of adenosine A2A receptor antagonists has received much interest in recent years for the treatment of neurodegenerative diseases. Based on docking studies, a new series of 2-arylbenzoxazoles has been identified as potential A2AR antagonists. Structure-affinity relationship was invest...