Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor

• Egile Nagusiak: Romain Duroux (Egilea), Nicolas Renault (Egilea), Joana Esteves Cuelho (Egilea), Laurence Agouridas (Egilea), David Blum (Egilea), Luisa V. Lopes (Egilea), Patricia Melnyk (Egilea), Saïd Yous (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The development of adenosine A2A receptor antagonists has received much interest in recent years for the treatment of neurodegenerative diseases. Based on docking studies, a new series of 2-arylbenzoxazoles has been identified as potential A2AR antagonists. Structure-affinity relationship was invest...