Effect of safranal on the response of cancer cells to topoisomerase I inhibitors: Does sequence matter?

• Príomhchruthaitheoirí: Lama Lozon (Údar), Ekram Saleh (Údar), Varsha Menon (Údar), Wafaa S. Ramadan (Údar), Amr Amin (Údar), Raafat El-Awady (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Lung and colorectal cancers are among the leading causes of death from cancer worldwide. Although topotecan (TPT), a topoisomerase1 inhibitor, is a first- and second-line drug for lung and colon cancers, the development of drug resistance and toxicity still remain as a major obstacle to chemotherape...