Effect of safranal on the response of cancer cells to topoisomerase I inhibitors: Does sequence matter?

• Main Authors: Lama Lozon (Author), Ekram Saleh (Author), Varsha Menon (Author), Wafaa S. Ramadan (Author), Amr Amin (Author), Raafat El-Awady (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lung and colorectal cancers are among the leading causes of death from cancer worldwide. Although topotecan (TPT), a topoisomerase1 inhibitor, is a first- and second-line drug for lung and colon cancers, the development of drug resistance and toxicity still remain as a major obstacle to chemotherape...