Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b+Ly6Chigh monocyte population expanded in sepsis-surviving mice

• Main Authors: Haruki Watanabe (Author), Minakshi Rana (Author), Myoungsun Son (Author), Pui Yan Chiu (Author), Yurong Fei-Bloom (Author), Kwangmin Choi (Author), Betty Diamond (Author), Barbara Sherry (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Sepsis survivors exhibit immune dysregulation that contributes to poor long-term outcomes. Phenotypic and functional alterations within the myeloid compartment are believed to be a contributing factor. Here we dissect the cellular and transcriptional heterogeneity of splenic CD11...