Polymorphism in the tumor necrosis factor-alpha gene (TNFA -308 G/A) is not associated with susceptibility to chronic periodontitis in a Brazilian population

• Main Authors: Paula Cristina Trevilatto (Author), Rui Barbosa de Brito Jr (Author), Raquel Mantuaneli Scarel-Caminaga (Author), Ana Paula de Souza Pardo (Author), Cleber Machado de Souza (Author), Antônio Wilson Sallum (Author), Sérgio Roberto Peres Line (Author)
• Format: Book
• Published: University Library System, University of Pittsburgh, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Tumor necrosis factor-alpha (TNF-α) is a major mediator of the immune-inflammatory response and may play an important role in the pathogenesis and progression of chronic periodontitis. Polymorphisms in the promoter of the TNFA gene have been associated with some types of inflammatory dise...