Novel DNA Aptamers for Parkinson's Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation

• Main Authors: Yuan Zheng (Author), Jing Qu (Author), Fenqin Xue (Author), Yan Zheng (Author), Bo Yang (Author), Yongchang Chang (Author), Hui Yang (Author), Jianliang Zhang (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is one of the most prevalent forms of synucleinopathies, and it is characterized neuropathologically by the presence of intracellular inclusions composed primarily of the protein α-synuclein (α-syn) in neurons. The previous immunotherapy targeting the α-syn in PD models...