The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Pathophysiology of Voiding Dysfunction and Pharmacological Therapy

• Main Authors: Masayuki Takeda (Author), Isao Araki (Author), Tsutomu Mochizuki (Author), Hiroshi Nakagomi (Author), Hideki Kobayashi (Author), Norifumi Sawada (Author), Hidenori Zakohji (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Normal lower urinary tract function consists of voiding and storage. During voiding, the pontine micturition reflex center orders the sacral parasympathetic nucleus to increase parasympathetic activity, resulting in urinary bladder detrusor contraction via activation of post-synaptic muscarinic rece...