ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fibrosis and dysfunction via regulating ACE2 shedding and myofibroblast transformation

• मुख्य लेखकों: Jing Cheng (लेखक), Fei Xue (लेखक), Cheng Cheng (लेखक), Wenhai Sui (लेखक), Meng Zhang (लेखक), Lei Qiao (लेखक), Jing Ma (लेखक), Xiaoping Ji (लेखक), Wenqiang Chen (लेखक), Xiao Yu (लेखक), Bo Xi (लेखक), Feng Xu (लेखक), Guohai Su (लेखक), Yuxia Zhao (लेखक), Panpan Hao (लेखक), Yun Zhang (लेखक), Cheng Zhang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A disintegrin and metalloprotease domain family protein 17 (ADAM17) is a new member of renin-angiotensin system (RAS) but its role in the pathogenesis of diabetic cardiomyopathy (DCM) is obscure. To test the hypothesis that ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fi...