A Functional RNAi Screen for Runx2-Regulated Genes Associated With Ectopic Bone Formation in Human Spinal Ligaments

• Main Authors: Masaki Kishiya (Author), Toshitada Sawada (Author), Kohta Kanemaru (Author), Hitoshi Kudo (Author), Takuya Numasawa (Author), Toru Yokoyama (Author), Sunao Tanaka (Author), Shigeru Motomura (Author), Kazumasa Ueyama (Author), Seiko Harata (Author), Satoshi Toh (Author), Ken-Ichi Furukawa (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic ossification in the spinal ligaments, which enlarges with time and compresses the spinal cord, resulting in serious neurological symptoms. We previously reported that Runx2 expression was enhanced in...