Low TGF-β1 plasma levels are associated with cognitive decline in Down syndrome

• Main Authors: Margherita Grasso (Author), Annamaria Fidilio (Author), Francesca L'Episcopo (Author), Marilena Recupero (Author), Concetta Barone (Author), Maria Giulia Bacalini (Author), Cristina Benatti (Author), Maria Concetta Giambirtone (Author), Giuseppe Caruso (Author), Donatella Greco (Author), Santo Di Nuovo (Author), Corrado Romano (Author), Raffaele Ferri (Author), Serafino Buono (Author), A. Claudio Cuello (Author), Johanna M. C. Blom (Author), Fabio Tascedda (Author), Pier Vincenzo Piazza (Author), Rafael De La Torre (Author), Filippo Caraci (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Almost all individuals with Down's syndrome (DS) show the characteristic neuropathological features of Alzheimer's disease (AD) by the age of 40, yet not every individual with DS experiences symptoms of AD later in life. Similar to neurotypical developing subjects, AD in people with DS las...