L-Citrulline Supplementation Reduces Blood Pressure and Myocardial Infarct Size under Chronic Intermittent Hypoxia, a Major Feature of Sleep Apnea Syndrome

• Main Authors: Bilgehan Ozcan (Author), Britanny Blachot-Minassian (Author), Stéphanie Paradis (Author), Lucile Mazière (Author), Marie Chambion-Diaz (Author), Sophie Bouyon (Author), Jean-Louis Pépin (Author), Vincent Pialoux (Author), Claire Arnaud (Author), Christophe Moinard (Author), Elise Belaidi (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intermittent hypoxia (IH) is a landmark of obstructive sleep apnea (OSA) at the core of the cardiovascular consequences of OSA. IH triggers oxidative stress, a major underlying mechanism for elevated blood pressure (BP) and increased infarct size. L-citrulline is an amino acid that has been demonstr...