Sex Differences in the Effects of a Kappa Opioid Receptor Antagonist in the Forced Swim Test

• Main Authors: Abigail Laman-Maharg (Author), Alexia V. Williams (Author), Mikaela D. Zufelt (Author), Vanessa A. Minie (Author), Stephanie Ramos-Maciel (Author), Rebecca Hao (Author), Evelyn Ordoñes Sanchez (Author), Tiffany Copeland (Author), Jill L. Silverman (Author), Angelina Leigh (Author), Rodney Snyder (Author), F. Ivy Carroll (Author), Timothy R. Fennell (Author), Brian C. Trainor (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is growing evidence that kappa opioid receptor (KOR) antagonists could be a useful class of therapeutics for treating depression and anxiety. However, the overwhelming majority of preclinical investigations examining the behavioral effects of KOR antagonists have been in male rodents. Here, we...