Hypoxia-induced downregulation of microRNA-186-5p in endothelial cells promotes non-small cell lung cancer angiogenesis by upregulating protein kinase C alpha

• Main Authors: Vivien Becker (Author), Xu Yuan (Author), Anne S. Boewe (Author), Emmanuel Ampofo (Author), Elke Ebert (Author), Johannes Hohneck (Author), Rainer M. Bohle (Author), Eckart Meese (Author), Yingjun Zhao (Author), Michael D. Menger (Author), Matthias W. Laschke (Author), Yuan Gu (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The tumor microenvironment stimulates the angiogenic activity of endothelial cells (ECs) to facilitate tumor vascularization, growth, and metastasis. The involvement of microRNA-186-5p (miR-186) in regulating the aberrant activity of tumor-associated ECs has so far not been clarified. In the present...