Modelling of a targeted nanotherapeutic 'stroma' to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt-β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson's disease

• Main Authors: Jing-Wei Zhao (Author), Sean C. Dyson (Author), Christina Kriegel (Author), Pam Tyers (Author), Xiaoling He (Author), Tarek M. Fahmy (Author), Su M. Metcalfe (Author), Roger A. Barker (Author)
• Format: Book
• Published: The Company of Biologists, 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The endogenous reparative capacity of the adult human brain is low, and chronic neurodegenerative disorders of the central nervous system represent one of the greatest areas of unmet clinical need in the developing world. Novel therapeutic strategies to treat them include: (i) growth factor delivery...