CRISPR/Cas-based CAR-T cells: production and application

• Main Authors: Ping Song (Author), Qiqi Zhang (Author), Zhiyong Xu (Author), Yueli Shi (Author), Ruirui Jing (Author), Dingcun Luo (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment approach for cancer, autoimmune disease, and heart disease. The integration of CAR into T cells is typically facilitated by retroviral or lentiviral vectors. However, the random insertion of CARs can lead to i...