The eIg technology to generate Ig-like bispecific antibodies

• Main Authors: Lennart Kühl (Author), Nadine Aschmoneit (Author), Roland E. Kontermann (Author), Oliver Seifert (Author)
• 格式: 图书
• 出版: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Bispecific antibodies have emerged as therapeutic molecules with a multitude of modes of action and applications. Here, we present a novel approach to solve the light-chain problem for the generation of bispecific Ig-like antibodies using the second constant domain of IgE (EHD2) genetically modified...