Altered Toll-Like Receptor Signalling in Children with Down Syndrome

• Main Authors: Dean Huggard (Author), W. J. Koay (Author), Lynne Kelly (Author), Fiona McGrane (Author), Emer Ryan (Author), Niamh Lagan (Author), Edna Roche (Author), Joanne Balfe (Author), T. Ronan Leahy (Author), Orla Franklin (Author), Ana Moreno-Oliveira (Author), Ashanty M. Melo (Author), Derek G. Doherty (Author), Eleanor J. Molloy (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toll-like receptors (TLRs) are the key in initiating innate immune responses. TLR2 is crucial in recognising lipopeptides from gram-positive bacteria and is implicated in chronic inflammation. Children with Down syndrome (DS) are prone to infections from these pathogens and have an increased risk of...