Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP⁵⁺, following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats

• Main Authors: Xuan Li (Author), Weina Duan (Author), Li Du (Author), Dongmei Chu (Author), Peng Wang (Author), Zhong Yang (Author), Xingguang Qu (Author), Zhenxing Yang (Author), Ines Batinic-Haberle (Author), Ivan Spasojevic (Author), David S. Warner (Author), James D. Crapo (Author), Miriam M. Treggiari (Author), Huaxin Sheng (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endovascular mechanical thrombectomy, combined with a tissue plasminogen activator (t-PA), is efficacious as a standard care for qualifying ischemic stroke patients. However, > 50% of thrombectomy patients still have poor outcomes. Manganese porphyrins, commonly known as mimics of superoxide dism...