A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β.

A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β.

New therapeutics are needed for neglected tropical diseases including Human African trypanosomiasis (HAT), a progressive and fatal disease caused by the protozoan parasites Trypanosoma brucei gambiense and T. b. rhodesiense. There is a need for simple, efficient, cost effective methods to identify n...

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Main Authors: Zachary T Swinney (Author), Brad A Haubrich (Author), Shuangluo Xia (Author), Chakk Ramesha (Author), Stephen R Gomez (Author), Paul Guyett (Author), Kojo Mensa-Wilmot (Author), David C Swinney (Author)
Format: Book
Published: Public Library of Science (PLoS), 2016-03-01T00:00:00Z.
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3rd Floor Main Library

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