Erythrocyte Folyl Polyglutamate Synthetase Activity Profiling as a Potential Tool for the Prediction of Methotrexate Efficacy and Toxicity in Rheumatoid Arthritis

• Главные авторы: Amar Kumar (Автор), Mudassar Iqbal Arain (Автор), Pooja Bhadbhade (Автор), Ryan Funk (Автор)
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• Опубликовано: MDPI AG, 2023-11-01T00:00:00Z.
• Предметы: article
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Methotrexate (MTX) is the cornerstone of therapy in the treatment of rheumatoid arthritis (RA). However, its efficacy and toxicity are variable and remain unpredictable. Interindividual variation in the metabolism of MTX by the enzyme folyl polyglutamate synthetase (FPGS) has been associated with re...