GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases

• Main Authors: Rita Sala (Author), Elisa Rioja-Blanco (Author), Naroa Serna (Author), Laura Sánchez-García (Author), Patricia Álamo (Author), Lorena Alba-Castellón (Author), Isolda Casanova (Author), Antonio López-Pousa (Author), Ugutz Unzueta (Author), María Virtudes Céspedes (Author), Esther Vázquez (Author), Antonio Villaverde (Author), Ramon Mangues (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal cancer (CRC) remains the third cause of cancer-related mortality in Western countries, metastases are the main cause of death. CRC treatment remains limited by systemic toxicity and chemotherapy resistance. Therefore, nanoparticle-mediated delivery of cytotoxic agents selectively to cance...