Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.

• Main Authors: Andrea Nühs (Author), Manu De Rycker (Author), Sujatha Manthri (Author), Eamon Comer (Author), Christina A Scherer (Author), Stuart L Schreiber (Author), Jean-Robert Ioset (Author), David W Gray (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arsenal of drugs available for treatment. The existing drugs have significant deficiencies so there is an urgent need for new and improved drugs. In the human host, Leishmania are obligate intracellular p...