Delivery of Quantum Dot-siRNA Nanoplexes in SK-N-SH Cells for BACE1 Gene Silencing and Intracellular Imaging

• Main Authors: Shengliang Li (Author), Zhonghua Liu (Author), Fengtao Ji (Author), Zijian Xiao (Author), Minjuan Wang (Author), Yingji Peng (Author), Yulin Zhang (Author), Ling Liu (Author), Zibing Liang (Author), Feng Li (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The fluorescent quantum dots (QDs) delivered small interfering RNAs (siRNAs) targeting β-secretase (BACE1) to achieve high transfection efficiency of siRNAs and reduction of β-amyloid (Aβ) in nerve cells. The CdSe/ZnS QDs with the conjugation of amino-polyethylene glycol (PEG) were synthesized. Nega...