2,4-Disubstituted pyridine derivatives are effective against intracellular and biofilm-forming tubercle bacilli

• Main Authors: M. Korycka-Machała (Author), M. Kawka (Author), J. Lach (Author), R. Płocińska (Author), A. Bekier (Author), B. Dziadek (Author), A. Brzostek (Author), P. Płociński (Author), D. Strapagiel (Author), M. Szczesio (Author), K. Gobis (Author), J. Dziadek (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It was recently reported that 4-substituted picolinohydrazonamides carrying hydrophilic cyclic amines, such as morpholine and pyrrolidine, at the end of their thiosemicarbazide chain have potent antimycobacterial activity in vitro at concentrations below 1 μg/ml. Here, two selected compounds, 2,4-di...