BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells

• Główni autorzy: Danny N. Legge (Autor), Alex P. Shephard (Autor), Tracey J. Collard (Autor), Alexander Greenhough (Autor), Adam C. Chambers (Autor), Richard W. Clarkson (Autor), Christos Paraskeva (Autor), Ann C. Williams (Autor)
• Format: Książka
• Wydane: The Company of Biologists, 2019-03-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

To decrease bowel cancer incidence and improve survival, we need to understand the mechanisms that drive tumorigenesis. Recently, B-cell lymphoma 3 (BCL-3; a key regulator of NF-κB signalling) has been recognised as an important oncogenic player in solid tumours. Although reported to be overexpresse...