BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells

• Main Authors: Danny N. Legge (Author), Alex P. Shephard (Author), Tracey J. Collard (Author), Alexander Greenhough (Author), Adam C. Chambers (Author), Richard W. Clarkson (Author), Christos Paraskeva (Author), Ann C. Williams (Author)
• Format: Book
• Published: The Company of Biologists, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To decrease bowel cancer incidence and improve survival, we need to understand the mechanisms that drive tumorigenesis. Recently, B-cell lymphoma 3 (BCL-3; a key regulator of NF-κB signalling) has been recognised as an important oncogenic player in solid tumours. Although reported to be overexpresse...