NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation

• Main Authors: Agata Habas (Author), Srinivasa Reddy Natala (Author), Jon K. Bowden-Verhoek (Author), Emily M. Stocking (Author), Diana L. Price (Author), Wolfgang Wrasidlo (Author), Douglas W. Bonhaus (Author), Martin B. Gill (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toll-like receptors (TLRs) play a critical role in innate immune system responses to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). A growing body of evidence suggests that excessive TLR-mediated innate immune system activation can lead to neuronal d...