Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier

• Main Authors: Jason Tien (Author), Dmitri Leonoudakis (Author), Ralitsa Petrova (Author), Vivian Trinh (Author), Tetsuya Taura (Author), Debapriya Sengupta (Author), Lisa Jo (Author), Angela Sho (Author), Yong Yun (Author), Eric Doan (Author), Anita Jamin (Author), Hussein Hallak (Author), David S. Wilson (Author), Jennifer R. Stratton (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTThe blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders. Here, we demonstrate that the transport of human a...