CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung

• Hoofdauteurs: Xueyan ePeng (Auteur), Meagan eMoore (Auteur), Huanxing eSun (Auteur), Robert eHomer (Auteur), Ye eGan (Auteur), Hong ePeng (Auteur), Erica eHerzog (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2014-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Pulmonary fibrosis is a difficult to treat, often fatal disease whose pathogenesis involves dysregulated TGF-b1 signaling. CD4+CD25+FoxP3+ Regulatory T cells (Tregs) exert important effects on host tolerance and arise from naïve CD4+ lymphocytes in response to TGF-b1. However the precise contributio...