CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung

• Main Authors: Xueyan ePeng (Author), Meagan eMoore (Author), Huanxing eSun (Author), Robert eHomer (Author), Ye eGan (Author), Hong ePeng (Author), Erica eHerzog (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary fibrosis is a difficult to treat, often fatal disease whose pathogenesis involves dysregulated TGF-b1 signaling. CD4+CD25+FoxP3+ Regulatory T cells (Tregs) exert important effects on host tolerance and arise from naïve CD4+ lymphocytes in response to TGF-b1. However the precise contributio...