Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19

AbstractIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitor...

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Main Authors: Karol Biernacki (Author), Olga Ciupak (Author), Mateusz Daśko (Author), Janusz Rachon (Author), Damian Flis (Author), Justyna Budka (Author), Iwona Inkielewicz-Stępniak (Author), Anna Czaja (Author), Janusz Rak (Author), Sebastian Demkowicz (Author)
Format: Book
Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
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3rd Floor Main Library

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