Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19

• मुख्य लेखकों: Karol Biernacki (लेखक), Olga Ciupak (लेखक), Mateusz Daśko (लेखक), Janusz Rachon (लेखक), Damian Flis (लेखक), Justyna Budka (लेखक), Iwona Inkielewicz-Stępniak (लेखक), Anna Czaja (लेखक), Janusz Rak (लेखक), Sebastian Demkowicz (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

AbstractIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitor...