Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19

• Hoofdauteurs: Karol Biernacki (Auteur), Olga Ciupak (Auteur), Mateusz Daśko (Auteur), Janusz Rachon (Auteur), Damian Flis (Auteur), Justyna Budka (Auteur), Iwona Inkielewicz-Stępniak (Auteur), Anna Czaja (Auteur), Janusz Rak (Auteur), Sebastian Demkowicz (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

AbstractIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitor...