Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19

• Những tác giả chính: Karol Biernacki (Tác giả), Olga Ciupak (Tác giả), Mateusz Daśko (Tác giả), Janusz Rachon (Tác giả), Damian Flis (Tác giả), Justyna Budka (Tác giả), Iwona Inkielewicz-Stępniak (Tác giả), Anna Czaja (Tác giả), Janusz Rak (Tác giả), Sebastian Demkowicz (Tác giả)
• Định dạng: Sách
• Được phát hành: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

AbstractIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitor...