Thiopurines correct the effects of autophagy impairment on intestinal healing - a potential role for ARHGAP18/RhoA

Thiopurines correct the effects of autophagy impairment on intestinal healing - a potential role for ARHGAP18/RhoA

The ATG16L1 T300A single-nucleotide polymorphism (SNP) is associated with Crohn's disease and causes an autophagy impairment. We have previously shown that this SNP is involved in the migration and hyperactivation of Rac1 in dendritic cells. Mucosal healing, currently the main target for inflam...

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Main Authors: Marileen M. C. Prins (Author), Francesca P. Giugliano (Author), Manon van Roest (Author), Stan F. J. van de Graaf (Author), Pim J. Koelink (Author), Manon E. Wildenberg (Author)
Format: Book
Published: The Company of Biologists, 2021-04-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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