Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma

• Main Authors: Korrapati V. Sathyasaikumar (Author), Verónica Pérez de la Cruz (Author), Benjamín Pineda (Author), Gustavo Ignacio Vázquez Cervantes (Author), Daniela Ramírez Ortega (Author), David W. Donley (Author), Paul L. Severson (Author), Brian L. West (Author), Flaviano Giorgini (Author), Jonathan H. Fox (Author), Robert Schwarcz (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). KMO activity has been implicated in several major brain diseases including Huntington&...