Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans

• Main Authors: Carmen Martínez-Fernández (Author), Milana Bergamino (Author), Alfonso Schiavi (Author), David Brena (Author), Natascia Ventura (Author), Sebastian Honnen (Author), Alberto Villanueva (Author), Ernest Nadal (Author), Julián Cerón (Author)
• Format: Book
• Published: The Company of Biologists, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin is the most common drug in first-line chemotherapy against solid tumors. We and others have previously used the nematode Caenorhabditis elegans to identify genetic factors influencing the sensitivity and resistance to cisplatin. In this study, we used C. elegans to explore cisplatin effect...