Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease

• Main Authors: Valentin Bragin (Author), Arturo Solís Herrera (Author), Jerzy Leszek (Author), Ludis Morales (Author), Mark E. Obrenovich (Author), Eldar Gasimov (Author), Hector H. Palacios (Author), Gjumrakch Aliev (Author), Dmitry Gokhman (Author)
• Format: Book
• Published: MDPI AG, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial dysfunction may be a principal underlying event in aging, including age-associated brain degeneration. Mitochondria provide energy for basic metabolic processes. Their decay with age impairs cellular metabolism and leads to a decline of cellular function. Alzheimer disease (AD) and cer...