MicroRNA-10a-3p Improves Cartilage Degeneration by Regulating CH25H-CYP7B1-RORα Mediated Cholesterol Metabolism in Knee Osteoarthritis Rats

• المؤلفون الرئيسيون: Xiaochen Li (مؤلف), Li Zhang (مؤلف), Xiaoqing Shi (مؤلف), Taiyang Liao (مؤلف), Nongshan Zhang (مؤلف), Yifan Gao (مؤلف), Runlin Xing (مؤلف), Peimin Wang (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Osteoarthritis (OA) is a worldwide degenerative joint disease that seriously impaired the quality of life of patients. OA has been established as a disease with metabolic disorder. Cholesterol 25-hydroxylase (CH25H) was proved to play a key role in cartilage cholesterol metabolism. However, the biol...