CYP2D6 Reduced Function Variants and Genotype/Phenotype Translations of CYP2D6 Intermediate Metabolizers: Implications for Personalized Drug Dosing in Psychiatry

• Main Authors: Espen Molden (Author), Marin M. Jukić (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Genetic differences in cytochrome P450 (CYP)-mediated metabolism have been known for several decades. The clinically most important polymorphic CYP enzyme is CYP2D6, which plays a key role in the metabolism of many antidepressants and antipsychotics, along with a range of non-psychiatric medications...