Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA

• Main Authors: Alexandra Sakai (Author), Gagandeep Singh (Author), Mahsa Khoshbakht (Author), Scott Bittner (Author), Christiane V. Löhr (Author), Randy Diaz-Tapia (Author), Prajakta Warang (Author), Kris White (Author), Luke Le Luo (Author), Blanton Tolbert (Author), Mario Blanco (Author), Amy Chow (Author), Mitchell Guttman (Author), Cuiping Li (Author), Yiming Bao (Author), Joses Ho (Author), Sebastian Maurer-Stroh (Author), Arnab Chatterjee (Author), Sumit Chanda (Author), Adolfo García-Sastre (Author), Michael Schotsaert (Author), John R. Teijaro (Author), Hong M. Moulton (Author), David A. Stein (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority. Here, we report that an antisense peptide-conjugated morpholino oligomer (PPMO) named 5'END-2, targeting a highly conserved sequence in the 5' UTR of SARS-CoV-2 genom...