A vitamin E long-chain metabolite and the inspired drug candidate α-amplexichromanol relieve asthma features in an experimental model of allergen sensitization

• Main Authors: Ida Cerqua (Author), Konstantin Neukirch (Author), Michela Terlizzi (Author), Elisabetta Granato (Author), Elisabetta Caiazzo (Author), Carla Cicala (Author), Armando Ialenti (Author), Raffaele Capasso (Author), Oliver Werz (Author), Rosalinda Sorrentino (Author), Denis Seraphin (Author), Jean-Jacques Helesbeux (Author), Giuseppe Cirino (Author), Andreas Koeberle (Author), Fiorentina Roviezzo (Author), Antonietta Rossi (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Benefits for vitamin E intake in diseases with inflammatory components have been described and related in part, to endogenously formed metabolites (long-chain metabolites, LCM). Here, we have evaluated the role of LCM in relieving asthma features. To this aim, the endogenous vitamin E metabolite α-1...