Deciphering the Path of <i>S-nitrosation</i> of Human Thioredoxin: Evidence of an Internal NO Transfer and Implication for the Cellular Responses to NO

• Main Authors: Vitor S. Almeida (Author), Lara L. Miller (Author), João P. G. Delia (Author), Augusto V. Magalhães (Author), Icaro P. Caruso (Author), Anwar Iqbal (Author), Fabio C. L. Almeida (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nitric oxide (NO) is a free radical with a signaling capacity. Its cellular functions are achieved mainly through <i>S-nitrosation</i> where thioredoxin (hTrx) is pivotal in the S-transnitrosation to specific cellular targets. In this study, we use NMR spectroscopy and mass spectrometry...