Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway

• Main Authors: Pengfei Li (Author), Jun Peng (Author), Yuexin Li (Author), Lili Gong (Author), Yali Lv (Author), He Liu (Author), Tianhong Zhang (Author), Song Yang (Author), Hongchuan Liu (Author), Jinglai Li (Author), Lihong Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Akebia saponin D (ASD) has a variety of biological activities and great medicinal potential, but its oral bioavailability is so low as to limit its development. Its pharmacokinetic profiles and excretion and metabolism in vivo have not been fully elucidated. This study was an attempt in...