Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α

BackgroundMetabolic remodeling plays a vital role in the development of heart failure. The trimetazidine can optimize fatty acid and glucose oxidation via inhibition of long-chain 3-ketoacyl CoA thiolase in the heart. So, trimetazidine commonly used in cardiovascular therapy as a myocardial metaboli...

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Main Authors: Huihui Li (Author), Zhi Ma (Author), Yajun Zhai (Author), Chao Lv (Author), Peng Yuan (Author), Feng Zhu (Author), Liping Wei (Author), Qi Li (Author), Xin Qi (Author)
Format: Book
Published: Frontiers Media S.A., 2020-08-01T00:00:00Z.
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