Genetic variations in HMGCR and PCSK9 and kidney function: a Mendelian randomization study

• Main Authors: Sehoon Park (Author), Seong Geun Kim (Author), Soojin Lee (Author), Yaerim Kim (Author), Semin Cho (Author), Kwangsoo Kim (Author), Yong Chul Kim (Author), Seung Seok Han (Author), Hajeong Lee (Author), Jung Pyo Lee (Author), Kwon Wook Joo (Author), Chun Soo Lim (Author), Yon Su Kim (Author), Dong Ki Kim (Author)
• Format: Book
• Published: The Korean Society of Nephrology, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background The genetically predicted lipid-lowering effect of HMGCR or PCSK9 variant can be used to assess drug proxy effects on kidney function. Methods Mendelian randomization (MR) analysis-identified HMGCR and PCSK9 genetic variants were used to predict the low-density lipoprotein (LDL) cholester...