Ultradeep targeted sequencing reveals low allele frequencies of somatic JAK2 and MPL variants in patients with abdominal vein thromboses: results of an ongoing prospective prevalence study in Mecklenburg-West Pomerania

• Main Authors: Luise Grunwald (Author), Christina Grosse-Thie (Author), Sina Sender (Author), Gudrun Knuebel (Author), Saskia Krohn (Author), Catrin Roolf (Author), Christian Junghanss (Author), Larissa Henze (Author), Hugo Murua Escobar (Author)
• Format: Book
• Published: BMC, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Myeloproliferative neoplasms are characterized by mutations in JAK2, MPL and CALR genes. Commonly in diagnostics and previous studies mainly sequencing and common PCR techniques under conventional detection limits are used. Splanchnic vein thromboses are rare, but often appear associated wi...