The Polycomb protein, Bmi1, regulates insulin sensitivity

• Главные авторы: Corey E. Cannon (Автор), Paul M. Titchenell (Автор), David N. Groff (Автор), Abdelfattah El Ouaamari (Автор), Rohit N. Kulkarni (Автор), Morris J. Birnbaum (Автор), Doris A. Stoffers (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2014-11-01T00:00:00Z.
• Предметы: article
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Objective: The Polycomb Repressive Complexes (PRC) 1 and 2 function to epigenetically repress target genes. The PRC1 component, Bmi1, plays a crucial role in maintenance of glucose homeostasis and beta cell mass through repression of the Ink4a/Arf locus. Here we have explored the role of Bmi1 in reg...