Complete Disruption of All Nitric Oxide Synthase Genes Causes Markedly Accelerated Renal Lesion Formation Following Unilateral Ureteral Obstruction in Mice In Vivo

• Main Authors: Naoya Morisada (Author), Masayoshi Nomura (Author), Hisae Nishii (Author), Yumi Furuno (Author), Mayuko Sakanashi (Author), Ken Sabanai (Author), Yumiko Toyohira (Author), Susumu Ueno (Author), Seiji Watanabe (Author), Masahito Tamura (Author), Tetsuro Matsumoto (Author), Akihide Tanimoto (Author), Yasuyuki Sasaguri (Author), Hiroaki Shimokawa (Author), Koichi Kusuhara (Author), Nobuyuki Yanagihara (Author), Akira Shirahata (Author), Masato Tsutsui (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: The role of nitric oxide (NO) derived from all three NO synthases (NOSs) in renal lesion formation remains to be fully elucidated. We addressed this point in mice lacking all NOSs. Renal injury was induced by unilateral ureteral obstruction (UUO). UUO caused significant renal lesion forma...