Identification of a novel SPT inhibitor WXP-003 by docking-based virtual screening and investigation of its anti-fungi effect

• Main Authors: Xin Wang (Author), Xin Yang (Author), Xin Sun (Author), Yi Qian (Author), Mengyao Fan (Author), Zhehao Zhang (Author), Kaiyuan Deng (Author), Zaixiang Lou (Author), Zejun Pei (Author), Jingyu Zhu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Serine palmitoyltransferase (SPT) plays the key role on catalysing the formation of 3-ketodihydrosphingosine, which is the first step of the de novo biosynthesis of sphingolipids. SPT is linked to many diseases including fungal infection, making it a potential therapeutic target. Thus, a logical doc...