Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8+ Immunity In Vivo

• Main Authors: Tzu-Yang Weng (Author), Chia-Jung Li (Author), Chung-Yen Li (Author), Yu-Hsuan Hung (Author), Meng-Chi Yen (Author), Yu-Wei Chang (Author), Yu-Hung Chen (Author), Yi-Ling Chen (Author), Hui-Ping Hsu (Author), Jang-Yang Chang (Author), Ming-Derg Lai (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clec4a has been reported to be an immune suppressor of dendritic cells (DCs), but its potential role in cancer therapy remains to be elucidated. The present study investigated whether downregulating the expression of Clec4a via skin delivery of small hairpin RNA (shRNA) using a gene gun produced str...