Novel Gliclazide Electrosprayed Nano-Solid Dispersions: Physicochemical Characterization and Dissolution Evaluation

• Main Authors: Khosro Adibkia (Author), Solmaz Ghajar (Author), Karim Osouli-Bostanabad (Author), Niloufar Balaei (Author), Shahram Emami (Author), Mohammad Barzegar-Jalali (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: In the current study, electrospraying was directed as a novel alternative approach to improve the physicochemical attributes of gliclazide (GLC), as a poorly water-soluble drug, by creating nanocrystalline/amorphous solid dispersions (ESSs). Methods: ESSs were formulated using Eudragit® RS1...