Synthesis, Antimicrobial Study, and Molecular Docking Simulation of 3,4-Dimethoxy-β-Nitrostyrene Derivatives as Candidate PTP1B Inhibitor

• Main Authors: Salman Alfarisi (Author), Mardi Santoso (Author), Alfinda Novi Kristanti (Author), Imam Siswanto (Author), Ni Nyoman Tri Puspaningsih (Author)
• 格式: 图书
• 出版: MDPI AG, 2020-09-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

A derivative series of 3,4-dimethoxy-β-nitrostyrene was synthesized through nitroaldol reaction, including a new compound of 3,4-ethylenedioxy-β-bromo-β-nitrostyrene. The antimicrobial activity effect of 3,4-alkyloxy modification of β-nitrostyrene was investigated. A molecular docking study was also...